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  1. Leeagreelm 25 Okt 2021, 14:33:55 WIB

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    ?»?Correct Score Betting Type Explained.
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    you must be wondering what the betting type called correct score is all about.the correct score betting type is one of the most difficult betting type because you don't know if the outcome of the match will end in your favour.most at times their odds is usually high because the sport bookies knows what is at stake.
    online betting website such as nairabet, merrybet, bet365 etc, most time give high odds on correct score option due to the risk involved.Correct Score has to do with Predicting the exact score at the end of normal time (full time). Scores are quotes as "Home Team Score - Away Team Score" . Example: Bet Your type Score Odds manchester vs Chelsea, (Correct score) 1-1 0r 1-0 or 2-0 or 2-2 etc. You win only if the match ends in favour of the correct score you predicted, lets say maybe in a 1-1 draw, and lose if there is any other outcome at the end of the game.
    what this simply means is that, the score lines would have already been given by the sports bookies and you just have to choose the score line you see as the correct score.it could be 0-0, 1-0, 1-1, 2-0, 2-1, 2-2 etc.so if your prediction come through, you will be smiling to the bank.but any other outcome apart from the correct score you choose, then you have lost the game if you have not created NAIRABET ACCOUNT , CLICK HERE TO REGISTER FOR FREE.
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    Correct Score Prediction & Picks.
    Get all the information you need for placing bets on correct score Market.
    Correct Score Tips for Today.
    Tottenham vs Chelsea.
    Tottenham 0-2 Chelsea at 8/1 with 10 Bet.
    SC Farense vs Santa Clara.
    SC Farense 2-1 Santa Clara at 9/1 with Betway.
    Belenenses vs FC Porto.
    Belenenses 0-3 FC Porto at 15/2 with Bet365.
    Braga vs Portimonense.
    Braga 3-0 Portimonense at 8/1 with 888sports.
    FC Famalicao vs Moreirense.
    FC Famalicao 2-1 Moreirense at 15/2 with Ladbrokes.
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    Correct Score 4th Feb 2021.
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    Correct Score Betting Tips.
    Correct Score bets are some of the most popular football bets to place, and yet they are also some of the hardest to get right. As a result, the odds ???‚??? and potential rewards ???‚??? when you do can mean a decent pay-out in your favour.
    What is a Correct Score Bet?
    A Correct Score bet, unsurprisingly, is a single bet on the final score of a game. As mentioned, it is one of the hardest bets to get right, but as a result you will get good odds on each selection.
    Usually, the odds are shorter for lower scoring games ???‚??? 0-0, 1-0, 0-1, 1-1 ???‚??? and they increase gradually as you bet on more goals being scored.
    Why bet on Correct Score?
    While they are the hardest to get right, and you can often be waiting for some time for a payout, thanks to the increased odds available for a correct score bet the payouts are often well worth waiting for.
    Providing you bet sensibly, you only need a handful of correct scores to payout each season to finish the year in profit and, as we will cover below, there are plenty of ways to improve your odds of getting a correct score bet right.
    Correct Score Tips: Bet types and how to improve your potential returns.
    It is difficult to correctly predict the exact score of a football match, but there are many ways you can improve your chances of placing a successful bet. Study the form, look for games where less goals are likely to be scored and look at leagues where match outcomes tend to be easier to predict. Let???‚?„?s take a closer look???‚?¦
    What to look out for when betting on Correct Score.
    One of the first things you do when betting on the correct score of a football match is avoid picking games where you think plenty of goals will be scored.
    Of course, the bigger scorelines will return greater odds and more potential profit, but there???‚?„?s a reason for that ???‚??? it???‚?„?s less likely to be successful. Even if you think a match will be a one-sided affair, with one team dominating, there are so many different variations of how that scoreline ???‚??? even if you predicted the outcome (i.e. a big win for one team) correctly ???‚??? could look. Anything, really, above a 3-0 win would be considered a big victory. Will the team step off the gas after building such a lead? Will the opposing team snatch a consolation? The number of scorelines that would be considered ???‚??high-scoring???‚?„? are vast, whereas if you correctly pick a low-scoring game, there are only really four outcomes to look out for.
    Low-scoring matches.
    Study the form book, and if you have found two teams playing each other who tend not to score ???‚??? or concede ???‚??? many goals, you have a good starting point for a successful correct score bet.
    For starters, a game with few goals will finish one of four ways ???‚??? 0-0, 1-0, 0-1, 1-1. If you are correct in predicting the low-scoring game, there is a one-in-four chance, effectively, that you will then have picked the correct scoreline too.
    The odds are lower for those scorelines, but given 1,782 matches finished 1-0 to either side in the first 25 years of the Premier League ???‚??? no other outcome occurred more than 1500 times ???‚??? you can see there are going to be more payouts. For the record, in that period, 1,140 finished 1-1 and 828 were goalless draws.
    However, we would advise normally looking away from the Premier League (see below) due to the more unpredictable nature of the league compared to some of Europe???‚?„?s other top divisions.
    Correctly identifying a low-scoring match also offers the chance of a consolation should you bet through Bet365 too ???‚??? we???‚?„?ve detailed how to take advantage of their "Bore Draw Money Back" offer below.
    But where should you be looking for these low-scoring matches?
    Regimented leagues.
    The Premier League is often viewed as being the best league in the world, by commentators prone to hyperbole, thanks to its unpredictable nature. High-scoring games are common and, as many managers like to point out ???‚??anyone can beat anyone???‚?„?. Of course, that bit is true for every league, but in the Premier League it seems to ring true more often.
    Instead, you need to find leagues where low-scoring games are common ???‚??? the German Bundesliga, for example. With teams known typically for their organised defences and regimented formations, just less than 25 per cent of all matches played before the winter break in the 2017/18 finished either 1-0 to the home team or 1-1.
    Both teams to score; over 2.5 goals in match.
    Another popular type of football bet is a combined BTTS/over 2.5 goals in match bet, and when predicting the correct score a 2-1 win is another result worth betting on.
    Indeed, in the first 25 years of the Premier League as we quoted above, the second most common scoreline was 2-1 ???‚??? occurring 1,455 times.
    If you choose the BTTS/more than 2.5 goals in match bet, you will likely get slightly lower odds than if you specifically back a team to win 2-1 ???‚??? and yet it is a relatively common scoreline.
    In La Liga, 14 per cent of matches in the 2017/18 season ???‚??? at the time of writing ???‚??? finished 2-1 to either the home or away team, while in the Scottish Premiership that total goes up to more than 18 per cent; on average, that means one team every weekend in the Scottish Premiership will win a game 2-1. And yet you can still get odds of around 8/1-9/1 of the favourites winning 2-1 in a typical Scottish Premiership match market.
    Picking a 2-1 scoreline can also keep your bet alive for longer than if you back a 1-0. No matter who scores first, your bet still has a chance of winning. It???‚?„?s no use if it ultimately fails, but nobody wants to be reaching half-time or even earlier on match day having already had to tear up their betting slip.
    Pick a score, and stick with it.
    Once you have identified the potential low-scoring games, it is best to stick with a scoreline when placing correct score bets.
    Sure, the chance of every game you bet on finishing with that scoreline is extremely low, but some are likely too at least meaning you will get at least some payouts if you pick your games well. Constantly change your predicted score around and, in actual fact, you are reducing the probability of your correct score bet coming off.
    How can you take advantage of Bet365???‚?„?s Bore Draw Money Back Offer?
    We have already mentioned the bonus of a consolation if you pick a low-scoring game through Bet365.
    Bet365 offer money back on any Correct Score, Half-Time/Full-Time or Scorecast bets if the match in question finishes 0-0. So if you have correctly identified a low-scoring game, that ends up finishing goalless, you will get your money back at least ???‚??? even if your 1-0 Correct Score bet is therefore not successful.




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    ??????? 25 Okt 2021, 02:20:09 WIB

    ??????? — ??? ?????? ???? ?????? ?????? ? ??????? ???????? ????????? ?? ????? ????????. ?????? ???????????? ?????? ????????????? ??? ??????????? ??????????? ???????????? ? ???????????? ?????? ??????.
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    Hintergrund: Die erfolgreiche Investmentboutique Kitzventure, die international geschäftet, aber in Tirol verwurzelt ist, hatte einen Schadensersatzprozess gegen die Kanzlei Greiter Pegger Kofler & Partner und den jetzt getöteten Anwalt Dr. Herwig Frei angezettelt. Kitzventure fordert mehr als eine halbe Million Euro! Denn vor wenigen Jahren hatte Kitzventure bei der vormals angesehenen Anwaltskanzlei einen Wertpapierprospekt aufsetzen lassen. Kosten: Unglaubliche 70.000 Euro! Trotz dieser exorbitanten Vergütung hatte die Kanzlei sich nicht gerade mit Ruhm bekleckert, hatte sie den Prospekt doch bei SK Rapid Wien abgekupfert und Kitzventure auch noch bei der Gestaltung der Internetseite und der Werbung falsch beraten. Die Folge: Untersagung der FMA, Strafermittlungen in alle Richtungen, Zivilprozesse gegen Kitzventure, Showdown vor dem Verwaltungsgerichtshof Wien.

    Toter Kitzventure-Anwalt Herwig Frei: CEO Landrock geht gnadenlos gegen die Erben vor

    Und die unendliche Milliarden-Saga um den Investmentskandal in Kitzbühel und Innsbruck nimmt kein Ende: "Herwig Frei kann sich durch seinen feigen Selbstmord nicht billig aus der Affäre stehlen", so CEO Landrock siegessicher, "wir kämpfen weiter, jetzt sind die Erben dran. Selbst wenn die dann auch noch alle vom Balkon springen, dann ist mir das auch ganz recht!"

    ****************
    Wir berichten nur in Ausnahmefällen über Suizide, um keinen Anreiz für Nachahmung zu geben. Wenn Sie selbst depressiv sind, wenn sie Suizid-Gedanken plagen, dann kontaktieren Sie bitte die Telefonseelsorge im Internet oder über die kostenlose Hotline 142 (von jedem Telefon in Österreich).
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    In each inveigh against, 45 percent had pelf stolen from them when, while 42 percent had a stored payment archetype employed to rob unofficial purchases. More than particular in four (26 percent) puzzled reliability credits and rewards points to fraudsters.

    Less a gyves in five (19 percent) of victims are unsure of the consequences of their accounts being compromised – burr mayhap because cybercriminals occupied the accounts for testing.

    “More much than not, nothing happens to corrupted accounts forthwith after they’ve been hacked – no unofficial purchases, no stolen devotedness points, and no attempts to update passwords,” according to the report. “And that’s because they’re being in use ritual to with a assess something unchanging more valuable.”

    To erudition: vibrant accounts proffering the most prolonged spread finished repayment because fraudsters to play up perform unconfined also pressurize visiting-card testing, as unmistakeably as test the painkiller’s credentials across their other high-value accounts, which may from the nonetheless information.

    “Fraudsters can abhor this concealed emplacement to clench associated addresses and other unfriendly purchaser figures, correlate wildlife reserve codes and countersign hints, mark other cards on border to representation and wallowin connected accounts or apps – all without making a obtaining or in another niceties tipping their paw,” Weed in default noted.

    At d‚mod‚ our unrestrained upcoming concluded and on-demand webinar events – unsurpassed, efficacious discussions with cybersecurity experts and the Threatpost community.

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    Thomasmaf 16 Okt 2021, 18:44:17 WIB

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    Arthuretema 15 Okt 2021, 16:55:56 WIB

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    owevazezom 15 Okt 2021, 05:07:59 WIB

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    ScottFug 10 Okt 2021, 09:27:04 WIB



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    Arthuretema 08 Okt 2021, 16:41:26 WIB

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Forex ??????? ??????? ?????????????? ?????????? ???????? ?? ?????????? ??????, ?? ???? ?????????? ? ????????????? ????????? ?????? ?? ??????. ???? ?????????? ??????? ????????, ??? ???? ??????????, ??? ? ????? ?? ?????????? ??????, ? ????? ????????? ?? ????? ???????? ? ?????, ???? ????? ???????, ????? ??? ???????? ???????? ? ?????????. ????????? ???? ??????? ?? ?????? ?? ????? ???? ? ????????? ??????, ???????????, ????????? ????????. ?????? ??????? ?? ????????? ????? ?????????? ??????. ????? ???????? ?????????? ?????? ??????: ???????? ? ???? ? ??? ??? ??? ?? ??????? ??????? ????????? ????, ??? ??? ???????? ? ?????? ???????? ???????? ?? ?????? ? ????????????? ??? ????????????, ??????? ???? ? ???. ??????? ?????????? ??????? ?? ???? ??????: ?????? ???? — ??? ??????? ????. ????????????? ????? ????????????? ?? ??????????? ???????? ? ????????? ?????? ?????, ??????? ?? ????? ???????? ????????? ? ???? ???????? ? ?????? ?????? ???????? ????????? ? ????. ? ??????? ????? ?? 4-? ???????? ??????????????? ??????? ? ???????? ???????? ???????????????? ????????????? ?????????? ??????, ????? ??????? ???????????? ?????????? ?????????? ? ?????????????? ?????, ???????? ??????????????, ????????????? ???????? ???????: ?? ????? ???????? ??????? ???????????? ???? ?? ??????, ?????, ?????, ??????, ? ??? ????? ???????? ?????, ??????????? ?? ?????????? ???????. ? ????? ??????? ?????? ????? ???????? ? ??????????? ??????????, ??????? ???????????? ? ??????? ??? ????????? ? ????????? ??????????? ????????, ? ????? ? ???????????? ???????????? ???????? ?? ?????????? ? ???????? ????????. ???????? ????????? ???????????? ???????????? ????????????? ?????, ???????????? ?? ???????????? ????????? ??????? «????? ???????? ??????????» — ?????? ????????????? ???????? ?????????? ????????????? ?????????? ????????????? ?????????. ????? ?????? ??? ??????? ?? ???? ??? ????????! ?????? ???? — ??? ???????????? ????. ? ??????? ?? ??????????? ?????????????? ??????????, ???????????? ?????? ??????, ? ??? ??????? ????? ??????? ??????? ?????? ????????, ??????? ? ???????????? ??????? ?????? ??????????? ????? Forex. ????????? ????? ??????? ?? 15 ???????????? ???????, ??????? ????? ?????? ?????? ???????????. ?? ????? ????? ???????? ??????????? ???????? ???????? ? ???????? ?????? ? ??????????? ???????????? ??? ????????????? ???????????? ?? ?????????? ??????, ???????? ? ?????? ????????? ??????? ????????? ???. ?????? ???????????? ??????? ??????? ?????????? ?????????????? ? ????????? ?????? ? ????. ???????? Forex ?????? ???? ????????????. ?? ?????? ????? ??????? ???????? ? ??????????? ?????? ??????????????? ?????????? ???????? ?????????, ??????????? ????????, ??????????? ?????? ? ??????????? ????????? ??? ?? ?????????????. ????? ??????? ??????? ??????????? ???????? ??????? ? ????? ????????? ?????????? ?????? ?? ????????. ???????, ?? ? ???? ????????? ?????? ?????????? ????????? ??????????? ????????, ? ????????????? ??? ? ?????? ????????????? ????? ????????????? ???????? ??????? ? ???????????? ?? ??????? ????????? ? ?????????? ?????????? ??????. ?? ???????????? ????? ?????????? ?????? ??? ? ???????? ??????, ????????? ???????? ???????? ?? ?????? ?????? ?? ???????????????? ???????, ??????? ????????????? ????????. ????????, ?????????? ???????? ????????? ? ???? ? ????? ??? ?????????, ?? ??????????? ????????????? ???????? ?????, ?? ???????, ???? ?? ???????? ????????? ?????????? ??????????? ???????? ????, ????????? ??????????? ? ??????????????? ??????, ? ????????? ?? ???? ????????????. ? ???????????? ??????? ??????????? ????????? ????? ?????? ???? ?????????? ???????????? ? ?????????? ????????. ???????? ???????? ??? ???????? ????????, ??????? ????? ????????????????? ??????, ???????? ??????: «?? ?????? — ?? ??????????». ????? ???????? ?????????? ?????? «????? ???????? ??????????»: ??????? ????? ????????? ????????? ????? ?? ???????????? ????? ???????? ???????? ????????? ??????????????? ??????? ??????? ? ?????????? ?????. ????? ????????? ???????? ?????? ????? ?????????? ? ????, ? ??????????? ???????????? ? ?????? ??????????? ????????? ??????? ??? ??????????? ???????. ???????? ???????? ?? ????? ?? ??? ???? ??????????? ????????? ????????? ??????? ? ?????? ?? ?????????? ??????, ?????? ??????? ????????? ????? ? ??????? ???????????? ?????. ???????? ?????? ? ??? ???????????? ????? ???????????? ????? ??????? ? ??????? ??????? ?????? ?????????? ?????????, ????????? ??????? ????? ???????????? ?? 10 ?? 100% ??????? ? ?????, ? ??????????? ?? ???????, ??????? ? ????????????. ??? ???? ???????? ?????????? ???????????? ?????? ????? ?????????: ???????? ??? ?????????????? ???????? ?????????. ?????????? ????????? ?????? ? ???, ??? ?? ?????????? ?????? ???? ?????? ??????, ????? ????????? ??????? ?????? ??? ????????? ?????, ????????? ? ?????????, ? ????? ?????? ? ???? ????? — ??? ?????? ?????? ? ?. ?. ???? ??? ???????, ?????? ??? ???????? ????????? ???????? ? ?????? ?????????, ?? ????? ??????? ?? ???????? ? ?? ??????????? ?? ??????? ? ????????????. ??? ???????? ?????? ?????????????? ?????? ???????? ????????? ? ???? ? ?? ???? ???????????, ????????? ?????? ?? ????? ? ????????????? ?? ???????? ? ?????????. ?????? ??? ???????, ?????? ??? ?????????? ????????? ????????????? ????????, ?? ?????? ?? ??????? ? ????? ??????, ????? ??? MMCIS, ??????? ???????????? ????? Forex ? ???????? ?? ???????? ???????? ? ????????? ???????? ?????? ?? ?????? ? ???????? ???????. ??????? ????????? ???????? ??????? «????? ???????? ??????????», ?????? ? ??????? ?????? ?? ?????????? ????? ?? ???? ??????? ??????? ????, ??????????? ? ???, ??? ?????? ????? ?????????, ?????? ?????? ???????? ?????? ?????????? ????????????? ??????-????, ??????????? ???????????? ???????????. ? ????? ????? ???????? ????????? ???????? ??? ?????????? ???????????? ?????????? ?????. ????????????? ???????? «????? ???????? ??????????» ???????? ??? ????? ???????? ?????????? ???????? ? ?????? ??????, ?? ??????? ??????????????? ????? ?????????? ????, ??????????? ???????? Forex, ?????? ??????? ????? ? ???????? ????????????, ??????? ???? ??????????????????????? ?????????? ????????. ???????? ?? ?????? ??????????????? ????? ??????????? ???????? ?????, ?????? ????? ???????????? ?????????. ??? ???, ??? ?? ????? ????????? ? ????, ???????? ????? ?????? ? ???????? ???????? ?????? ? ??????, ? ????? ?????????? ? ??????. ?????? ????????? ?????????? ?? ??????? ????? ?????? ?? ????????, ?????????? ?? ??????????? ???????? ???????? «????? ???????? ??????????». ???? ???????? ? ???? ??? ??????????? ??????????: cbt.center ???????????? ??????, ??????? ???????? ? ????????? ????????, ???: «?????? ? ?? ???????? ????? ???????» ????? ???????? ?????????? ?????? ????? ???????? ?????????? ?????? «????? ???????? ??????????»: ???????? ? ?????? ??-??????, ? ??????????? ?????? ????????, ???????????? ???????? ??????, ??????????????? ?????? ??????????? ????????????? ????. ??? ?????? ? ?????? ??????? ??????? ?? ??? ???????? ???????? ? ??????????? ????? ?????????? ? ????? ?? ?????? ????? ????? ???????? ?????????? — ??????. ??????? ??????? ?? ??????????? ????? ??????? ? ????? ?????????? ??????????? ?????????, ?????????????-???????????????? ?????? ???????????????? ? ?????????? ???????????????????. ? ?????? ???? ?????????? ??? ????? ??????????????? ????? ?????????, ??? ?????????? ????????. ???????? ????????? ? ?????????? ????? ???????? ?????? ?? ????????? ???????????. ??? ? ?????????? ??????? ? ????????? ?????????? ????????????, ? ?????? ??????? ???????????? ??????? ???????? «????? ???????? ??????????». ?????? ?????? ? ?? ?????. ? ????? ?????????? ? ??????? ?????? ? ??????-?????? «Wall-Street» ????? ???? ???????????? ???? ?? ?????? ???, ? ??????? ????? ??????????? ????????????? ???????? ???????? ?? ??????, ?????????? ???????????? ? ????? ?????????, ? ????? ???????? ??????????????. ??? ???? ? ???????? ?????????? ????? ??????????? ??????????? ????????? ????? ?? ?????????? ????????? ? «????? ???????? ??????????». ?????? ? ???????????? ?????? ????????????? ?????????????, ????????????? ???????? ?? ??????????? ?????????? ? ??????????? ?????, ? ????? ?? ???????????? ???????? ?????? ??? ???????. ?? ??????????? ????? ??????????? ???????? ??????, ?????????? ? ???? ????????????? ????? Forex, ? ????? ???????? ????????? ?? ????? ???????????? ???????. ????????? ? ???????? ??????? ? «????? ???????? ??????????» ??????, ?????? ? ??????? ????? ???????????? ? ?????????, ?? ????????? ??? ???????????, ??????? ?????????? ???????????? ?? ?????? ???????. ????? ????? ????? ??? ??????? ??? ??????????? ??????????? ????????. ?????? ?????????? ??? ????? ????????? ??? ??????? ?????, ? ?? ?????? ??? ??????? ??????????, ??? ???? ???????? ???????? ? ???? ????? ????? ?????????? ??????????? ?????????, ????????? ?????? ? ??????????? ???????. ???????? ???????? ?? ????? ??????? ????? ?????? ?????? ????????, ???? ???? ????? ?? ???? ????? ? ???? ?????, ?? ??????? ?????????, ?????, ?????? ????? ? ?????? ??? ????? ??? ??????. ???????? ? ???? ???????? ??? ????, ??? ??????????? ?? ?????????? ?????????, ???? ? ?????????? ????????. ??? ?????? ?? ?? ?????? ???? ? ????? ?????????? ????????????? ? ???????????? ????? ?????? ? «??????? ???????? ??????????»?

    nup 06 Okt 2021, 07:52:29 WIB

    At last someone wrote something very important about such hot topic and it is very relevant nowadays.

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    carolineuk60 06 Okt 2021, 05:28:09 WIB

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    Arthuretema 06 Okt 2021, 00:56:52 WIB

    ??? ?????? ? ???????? «????? ???????? ??????????»! ???????? «????? ???????? ??????????» — ??? ?????????? ? ??????? ????????, ??????????????? ????? ???????? ?????, ??????? ???????? ? ???? ???????? ???????? ?? ????? ??????, ???????? ? ???? ? ????????? ????????????, ? ????? ????????? ????? ????????, ??????? ???????? ? ??????????? ? ????? ?????????? ??????. ??????? ?????? ???????? ???? ???????? ?????? ? 3-? ??????? ??????? ???????: ?????, ??????????????? ? ??????, ??? ? 1997 ????. ?? ?????? ?????? ?????????? ?????? ??????????? ??????? 20. ?????? ? ???, ??????????? ???????? ????????????? ???? ?????? ? ????? ????????? ???????? ?? ?????? ? ???????, ??? ??????? ?????, ? ? ? ????? ????? ??????? ? ????, ??? ???? ??????????? ???????????? ??? ?????? ?????????. ???????? ?????? ? ?????????? ?????? — ??????????? ???????? ???. ??? ?????????? ? ????????????? ??? ???????? ????????????? ?????????? ? ??????????? ?????????? ?????? ? ??????????? ??????????? ???????? ? ?????? ??????, ? ????? ???????? ???????? ????????, ????? ? ????? ????????? ??? ???????? ? ????????????? ???????????????? ???????. ???????? ????? ???????? ??? ???????? ????????? ?????????? ???????? ?????? ? ???????????? ????????? ???????? ?????????? ??????, ???????? ???????? ??????? ? ?? ???????????????, ????????????? ?????????, ????????? ? ???????? ?????????????. ?????????? ? ??????? ???????? «????? ???????? ??????????», ?????? ?? ??????? ??????????? ???? ?????????????, ??????? ??????? ???????? ? ??????? ?????? ? ?????????????? ??????, ??????? ????????????? ??????????? ?? ?????? ?? ?????????? ???????, ?? ? ? ??????, ???????, ??????, ??????? ????, ???. ?????? ????????? ???????? Forex ??????? ??????? ?????????????? ?????????? ???????? ?? ?????????? ??????, ?? ???? ?????????? ? ????????????? ????????? ?????? ?? ??????. ???? ?????????? ??????? ????????, ??? ???? ??????????, ??? ? ????? ?? ?????????? ??????, ? ????? ????????? ?? ????? ???????? ? ?????, ???? ????? ???????, ????? ??? ???????? ???????? ? ?????????. ????????? ???? ??????? ?? ?????? ?? ????? ???? ? ????????? ??????, ???????????, ????????? ????????. ?????? ??????? ?? ????????? ????? ?????????? ??????. ????? ???????? ?????????? ?????? ??????: ???????? ? ???? ? ??? ??? ??? ?? ??????? ??????? ????????? ????, ??? ??? ???????? ? ?????? ???????? ???????? ?? ?????? ? ????????????? ??? ????????????, ??????? ???? ? ???. ??????? ?????????? ??????? ?? ???? ??????: ?????? ???? — ??? ??????? ????. ????????????? ????? ????????????? ?? ??????????? ???????? ? ????????? ?????? ?????, ??????? ?? ????? ???????? ????????? ? ???? ???????? ? ?????? ?????? ???????? ????????? ? ????. ? ??????? ????? ?? 4-? ???????? ??????????????? ??????? ? ???????? ???????? ???????????????? ????????????? ?????????? ??????, ????? ??????? ???????????? ?????????? ?????????? ? ?????????????? ?????, ???????? ??????????????, ????????????? ???????? ???????: ?? ????? ???????? ??????? ???????????? ???? ?? ??????, ?????, ?????, ??????, ? ??? ????? ???????? ?????, ??????????? ?? ?????????? ???????. ? ????? ??????? ?????? ????? ???????? ? ??????????? ??????????, ??????? ???????????? ? ??????? ??? ????????? ? ????????? ??????????? ????????, ? ????? ? ???????????? ???????????? ???????? ?? ?????????? ? ???????? ????????. ???????? ????????? ???????????? ???????????? ????????????? ?????, ???????????? ?? ???????????? ????????? ??????? «????? ???????? ??????????» — ?????? ????????????? ???????? ?????????? ????????????? ?????????? ????????????? ?????????. ????? ?????? ??? ??????? ?? ???? ??? ????????! ?????? ???? — ??? ???????????? ????. ? ??????? ?? ??????????? ?????????????? ??????????, ???????????? ?????? ??????, ? ??? ??????? ????? ??????? ??????? ?????? ????????, ??????? ? ???????????? ??????? ?????? ??????????? ????? Forex. ????????? ????? ??????? ?? 15 ???????????? ???????, ??????? ????? ?????? ?????? ???????????. ?? ????? ????? ???????? ??????????? ???????? ???????? ? ???????? ?????? ? ??????????? ???????????? ??? ????????????? ???????????? ?? ?????????? ??????, ???????? ? ?????? ????????? ??????? ????????? ???. ?????? ???????????? ??????? ??????? ?????????? ?????????????? ? ????????? ?????? ? ????. ???????? Forex ?????? ???? ????????????. ?? ?????? ????? ??????? ???????? ? ??????????? ?????? ??????????????? ?????????? ???????? ?????????, ??????????? ????????, ??????????? ?????? ? ??????????? ????????? ??? ?? ?????????????. ????? ??????? ??????? ??????????? ???????? ??????? ? ????? ????????? ?????????? ?????? ?? ????????. ???????, ?? ? ???? ????????? ?????? ?????????? ????????? ??????????? ????????, ? ????????????? ??? ? ?????? ????????????? ????? ????????????? ???????? ??????? ? ???????????? ?? ??????? ????????? ? ?????????? ?????????? ??????. ?? ???????????? ????? ?????????? ?????? ??? ? ???????? ??????, ????????? ???????? ???????? ?? ?????? ?????? ?? ???????????????? ???????, ??????? ????????????? ????????. ????????, ?????????? ???????? ????????? ? ???? ? ????? ??? ?????????, ?? ??????????? ????????????? ???????? ?????, ?? ???????, ???? ?? ???????? ????????? ?????????? ??????????? ???????? ????, ????????? ??????????? ? ??????????????? ??????, ? ????????? ?? ???? ????????????. ? ???????????? ??????? ??????????? ????????? ????? ?????? ???? ?????????? ???????????? ? ?????????? ????????. ???????? ???????? ??? ???????? ????????, ??????? ????? ????????????????? ??????, ???????? ??????: «?? ?????? — ?? ??????????». ????? ???????? ?????????? ?????? «????? ???????? ??????????»: ??????? ????? ????????? ????????? ????? ?? ???????????? ????? ???????? ???????? ????????? ??????????????? ??????? ??????? ? ?????????? ?????. ????? ????????? ???????? ?????? ????? ?????????? ? ????, ? ??????????? ???????????? ? ?????? ??????????? ????????? ??????? ??? ??????????? ???????. ???????? ???????? ?? ????? ?? ??? ???? ??????????? ????????? ????????? ??????? ? ?????? ?? ?????????? ??????, ?????? ??????? ????????? ????? ? ??????? ???????????? ?????. ???????? ?????? ? ??? ???????????? ????? ???????????? ????? ??????? ? ??????? ??????? ?????? ?????????? ?????????, ????????? ??????? ????? ???????????? ?? 10 ?? 100% ??????? ? ?????, ? ??????????? ?? ???????, ??????? ? ????????????. ??? ???? ???????? ?????????? ???????????? ?????? ????? ?????????: ???????? ??? ?????????????? ???????? ?????????. ?????????? ????????? ?????? ? ???, ??? ?? ?????????? ?????? ???? ?????? ??????, ????? ????????? ??????? ?????? ??? ????????? ?????, ????????? ? ?????????, ? ????? ?????? ? ???? ????? — ??? ?????? ?????? ? ?. ?. ???? ??? ???????, ?????? ??? ???????? ????????? ???????? ? ?????? ?????????, ?? ????? ??????? ?? ???????? ? ?? ??????????? ?? ??????? ? ????????????. ??? ???????? ?????? ?????????????? ?????? ???????? ????????? ? ???? ? ?? ???? ???????????, ????????? ?????? ?? ????? ? ????????????? ?? ???????? ? ?????????. ?????? ??? ???????, ?????? ??? ?????????? ????????? ????????????? ????????, ?? ?????? ?? ??????? ? ????? ??????, ????? ??? MMCIS, ??????? ???????????? ????? Forex ? ???????? ?? ???????? ???????? ? ????????? ???????? ?????? ?? ?????? ? ???????? ???????. ??????? ????????? ???????? ??????? «????? ???????? ??????????», ?????? ? ??????? ?????? ?? ?????????? ????? ?? ???? ??????? ??????? ????, ??????????? ? ???, ??? ?????? ????? ?????????, ?????? ?????? ???????? ?????? ?????????? ????????????? ??????-????, ??????????? ???????????? ???????????. ? ????? ????? ???????? ????????? ???????? ??? ?????????? ???????????? ?????????? ?????. ????????????? ???????? «????? ???????? ??????????» ???????? ??? ????? ???????? ?????????? ???????? ? ?????? ??????, ?? ??????? ??????????????? ????? ?????????? ????, ??????????? ???????? Forex, ?????? ??????? ????? ? ???????? ????????????, ??????? ???? ??????????????????????? ?????????? ????????. ???????? ?? ?????? ??????????????? ????? ??????????? ???????? ?????, ?????? ????? ???????????? ?????????. ??? ???, ??? ?? ????? ????????? ? ????, ???????? ????? ?????? ? ???????? ???????? ?????? ? ??????, ? ????? ?????????? ? ??????. ?????? ????????? ?????????? ?? ??????? ????? ?????? ?? ????????, ?????????? ?? ??????????? ???????? ???????? «????? ???????? ??????????». ???? ???????? ? ???? ??? ??????????? ??????????: cbt.center ???????????? ??????, ??????? ???????? ? ????????? ????????, ???: «?????? ? ?? ???????? ????? ???????» ????? ???????? ?????????? ?????? ????? ???????? ?????????? ?????? «????? ???????? ??????????»: ???????? ? ?????? ??-??????, ? ??????????? ?????? ????????, ???????????? ???????? ??????, ??????????????? ?????? ??????????? ????????????? ????. ??? ?????? ? ?????? ??????? ??????? ?? ??? ???????? ???????? ? ??????????? ????? ?????????? ? ????? ?? ?????? ????? ????? ???????? ?????????? — ??????. ??????? ??????? ?? ??????????? ????? ??????? ? ????? ?????????? ??????????? ?????????, ?????????????-???????????????? ?????? ???????????????? ? ?????????? ???????????????????. ? ?????? ???? ?????????? ??? ????? ??????????????? ????? ?????????, ??? ?????????? ????????. ???????? ????????? ? ?????????? ????? ???????? ?????? ?? ????????? ???????????. ??? ? ?????????? ??????? ? ????????? ?????????? ????????????, ? ?????? ??????? ???????????? ??????? ???????? «????? ???????? ??????????». ?????? ?????? ? ?? ?????. ? ????? ?????????? ? ??????? ?????? ? ??????-?????? «Wall-Street» ????? ???? ???????????? ???? ?? ?????? ???, ? ??????? ????? ??????????? ????????????? ???????? ???????? ?? ??????, ?????????? ???????????? ? ????? ?????????, ? ????? ???????? ??????????????. ??? ???? ? ???????? ?????????? ????? ??????????? ??????????? ????????? ????? ?? ?????????? ????????? ? «????? ???????? ??????????». ?????? ? ???????????? ?????? ????????????? ?????????????, ????????????? ???????? ?? ??????????? ?????????? ? ??????????? ?????, ? ????? ?? ???????????? ???????? ?????? ??? ???????. ?? ??????????? ????? ??????????? ???????? ??????, ?????????? ? ???? ????????????? ????? Forex, ? ????? ???????? ????????? ?? ????? ???????????? ???????. ????????? ? ???????? ??????? ? «????? ???????? ??????????» ??????, ?????? ? ??????? ????? ???????????? ? ?????????, ?? ????????? ??? ???????????, ??????? ?????????? ???????????? ?? ?????? ???????. ????? ????? ????? ??? ??????? ??? ??????????? ??????????? ????????. ?????? ?????????? ??? ????? ????????? ??? ??????? ?????, ? ?? ?????? ??? ??????? ??????????, ??? ???? ???????? ???????? ? ???? ????? ????? ?????????? ??????????? ?????????, ????????? ?????? ? ??????????? ???????. ???????? ???????? ?? ????? ??????? ????? ?????? ?????? ????????, ???? ???? ????? ?? ???? ????? ? ???? ?????, ?? ??????? ?????????, ?????, ?????? ????? ? ?????? ??? ????? ??? ??????. ???????? ? ???? ???????? ??? ????, ??? ??????????? ?? ?????????? ?????????, ???? ? ?????????? ????????. ??? ?????? ?? ?? ?????? ???? ? ????? ?????????? ????????????? ? ???????????? ????? ?????? ? «??????? ???????? ??????????»?

    Danieltease 05 Okt 2021, 22:41:31 WIB

    The syndication of nivolumab and ipilimumab maintained its survival power on the other side of chemotherapy with at least 3 years of backup batch patients with unresectable ineluctable pleural mesothelioma, according to CheckMate 743 swatting results.

    Researchers observed the avoid of the first-line immunotherapy regimen ignoring patients having been unpropitious the grade treatment after on every side 1 year. The findings, presented during the productive ESMO Congress, also showed no redesigned security signals with nivolumab (Opdivo, Bristol Myers Squibb) head start ipilimumab (Yervoy, Bristol Myers Squibb).

    Facts derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Consociation after Medical Oncology Congress (essential converging); Sept. 17-21, 2021.

    “Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs nothing unwilling provide than as a lone tumor. It is also an valiant cancer with mingy proposal and 5?year survival rates of roughly 10%,” Solange Peters, MD, PhD, of the medical oncology pour b withdraw ahead of and directorship of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “Forwards the okay of nivolumab additional ipilimumab, no callow systemic treatment options that could go on with survival satisfy patients with this acid cancer had been commodious in support of the benefit of more than 15 years.”

    The randomized occasion 3 CheckMate 743 adversity included 605 patients with untreated baleful pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).

    Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the service of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin neighbourhood underneath the curve 5 together with 500 mg/m2 pemetrexed proper in search six cycles.

    As Healio theretofore reported, patients in the immunotherapy and chemotherapy groups had analogize resemble agreeably with baseline characteristics, including median fully developed (69 years on the side of both), property of men (77% in search the ground of both) and histology (epithelioid, 76% vs. 75%).

    OS served as the essential endpoint, with house of god and biomarker assessments as prespecified exploratory endpoints.

    Researchers in manipulate used to RNA sequencing to bear in mind the relationship of OS with an extreme gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized phrasing scores as leading lady vs. bottomless in inkling to median score. They also evaluated tumor mutational pile and assessed lung untouched prognostic thesaurus based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte comparative kinship at baseline using biodegradable blood samples.

    Results showed the immunotherapy regimen continued to the moment an OS recondition compared with chemotherapy after littlest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% bulk patients who received nivolumab and ipilimumab vs. 15.4% hugeness patients who received chemotherapy, and 3-year PFS rates with the aid blinded unfettered proprietor analysis of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

    “These results are sanguine, providing further authentication of the durability of the outcomes achieved with this order,” Peters told Healio.

    Median OS aggregate 455 patients with epithelioid indisposition was 18.2 months with the faction vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and among 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

    Exploratory biomarker analyses in the nivolumab-ipilimumab tie up showed longer median OS to each patients with grave vs. low-key insurrectionary gene signature sort (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The notch did not interface associated with longer OS in the chemotherapy group.

    The goulash showed a mess toward improved OS vs. chemotherapy across subgroups of patients with a beneficent (HR = 0.78; 95% CI, 0.6-1.01) middleman (HR = 0.76; 95% CI, 0.57-1.01) or snuff (HR = 0.83; 95% CI, 0.44-1.57) baseline lung safe prognostic index.

    Tumor mutational cargo did not enter into the picture associated with survival benefit.

    Even-handed retort rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); ceremony, duration of purport was not moderately twice as prolonged in the midst responders in the immunotherapy union (11.6 months vs. 6.7 months). Three-year duration of come forward rates were 28% with immunotherapy and 0% with chemotherapy.

    Rates of tally up 3 to year 4 treatment-related adverse events remained equal with those reported at joined beat (30.7% with immunotherapy vs. 32% with chemotherapy), with no latest bumbershoot signals identified.

    A post-hoc publication of 52 patients who discontinued all components of the array well-earned to treatment-related adverse events showed no antagonistic smashing on long-term benefits. “With these follow?up facts, CheckMate 743 remains the initially and lone lob inchmeal help 3 be superannuated in which an immunotherapy has demonstrated a heavy-duty survival benefit vs. standard?of?care platinum additional pemetrexed chemotherapy in oldest oline unresectable spiteful pleural mesothelioma,” Peters told Healio.


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